Is Infrared Spectroscopy Ready for the Clinic?

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Clinical Diagnostics

Background:

• Fourier transform-infrared spectroscopy (FT-IR) offers a rapid, cost-effective method for molecular fingerprinting of biological samples.
• FT-IR leverages vibrational transitions of chemical bonds upon interaction with infrared light to generate unique spectral data.
• Existing research indicates FT-IR performance is competitive with or superior to conventional diagnostic techniques, showing promise for early disease detection.

Purpose of the Study:

• To outline the significant clinical potential of FT-IR diagnostics.
• To address current barriers hindering the routine adoption of FT-IR in clinical laboratories.
• To discuss future perspectives and technological advancements for facilitating FT-IR clinical translation.

Main Methods:

• This perspective reviews existing research and identifies barriers to clinical translation.
• It analyzes the application of FT-IR across various diagnostic frameworks: biofluid analysis, histopathology, cytology, microbiology, and biomarker discovery.
• Technological advancements relevant to clinical adoption are considered.

Main Results:

• FT-IR demonstrates considerable potential for revolutionizing clinical settings through comprehensive chemical profiling.
• Despite promising performance, routine clinical adoption remains elusive due to various barriers.
• The perspective highlights the need to address stakeholder concerns for successful translation.

Conclusions:

• FT-IR diagnostics hold substantial promise for earlier, accessible disease detection and improved patient outcomes.
• Addressing current barriers through stakeholder engagement and technological innovation is crucial for widespread clinical implementation.
• Future advancements in FT-IR technology are expected to facilitate its integration into routine clinical practice.