Combinatorial immunotherapy strategies: most gods throw dice, but fate plays chess

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

The study examined the influence of jumping ability on throwing speed and accuracy in 35 male handball players. Professional players demonstrated superior accuracy and speed compared to amateurs. Jumping ability was identified as a robust predictor of competitive level and exhibited a positive correlation with throwing...

Fate mapping is a technique used to understand how embryonic cells divide, differentiate, and migrate during development. In classic fate mapping experiments, cells in different areas of an embryo are labeled with a chemical dye and then tracked to determine which tissues or structures they form. Technological improvements now allow for individual cells to be marked and traced throughout embryonic development and adulthood.
This video reviews the concepts behind fate mapping, and then details a...

We describe an approach to reliably generate chimeric antigen receptor (CAR) T cells and test their differentiation and function in vitro and in...