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Related Concept Videos

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans04:54

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Related Experiment Video

Updated: Jan 19, 2026

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans
04:54

Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans

Published on: June 2, 2023

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Lipokines and Thermogenesis.

Matthew D Lynes1, Sean D Kodani1, Yu-Hua Tseng1,2

  • 1Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

Endocrinology
|September 11, 2019
PubMed
Summary

Adaptive thermogenesis, regulated by lipokines, generates heat in brown and beige fat. These lipid signaling molecules, including oleoylethanolamine and endocannabinoids, offer potential therapeutic targets for obesity.

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Last Updated: Jan 19, 2026

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Area of Science:

  • Metabolic Physiology
  • Endocrinology
  • Lipid Signaling

Background:

  • Adaptive thermogenesis is a critical metabolic process for heat generation, primarily in adipose tissues.
  • Lipokines, lipid-derived hormones, are key regulators of thermogenesis and energy expenditure.
  • Technological advancements have enabled the discovery of novel thermogenic lipokines.

Purpose of the Study:

  • To review the role of lipokines in regulating adaptive thermogenesis.
  • To highlight specific families of lipokines involved in thermoregulation.
  • To discuss the therapeutic potential of these lipokines in metabolic disorders.

Main Methods:

  • Literature review of scientific studies on thermogenesis and lipokines.
  • Analysis of biosynthesis, regulation, and effects of key lipokines.
  • Discussion of technological advances in identifying lipid biomarkers.

Main Results:

  • Several lipokine families, including oleoylethanolamine, endocannabinoids, prostaglandin E2, and 12,13-diHOME, regulate thermogenesis.
  • These lipokines act through diverse pathways to modulate energy expenditure.
  • Identification of new lipid biomarkers enhances understanding of thermogenic mechanisms.

Conclusions:

  • Lipokines are crucial mediators of adaptive thermogenesis.
  • Specific lipokines represent promising therapeutic targets for obesity and metabolic diseases.
  • Further research into lipokine pathways can unlock new strategies for metabolic health.