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Siblings with left ventricular diverticulum and hypertrophic cardiomyopathy
Y Shizukuda1, H Murakami, M Iwakura
1Second Department of Internal Medicine, Sapporo Medical College.
Journal of Cardiology
|September 1, 1988
Summary
This study reports rare siblings with a left ventricular diverticulum and hypertrophic cardiomyopathy. This familial occurrence of left ventricular diverticulum, especially with hypertrophic cardiomyopathy, is exceptionally uncommon.
Area of Science:
- Cardiology
- Genetics
- Medical Imaging
Background:
- Hypertrophic cardiomyopathy (HCM) is a primary cardiac disorder.
- Left ventricular diverticulum (LVD) is a rare congenital anomaly.
Observation:
- Two siblings presented with a rare combination of LVD and HCM.
- Both cases involved a posterior wall LVD and mitral valve prolapse.
- Diagnostic imaging included echocardiography and left ventriculography.
Findings:
- Endomyocardial biopsies confirmed findings consistent with HCM in both siblings.
- Coronary angiograms were normal, ruling out ischemic causes.
- This represents a potential familial pattern of LVD, previously unreported.
Implications:
- Highlights the rare association of LVD with HCM.
- Suggests a possible genetic component in LVD presentation.
- Emphasizes the importance of comprehensive cardiac evaluation in affected families.