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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Herein, we present a protocol to demonstrate the utility of dermoscopy in rheumatic diseases. In addition, we described the dermoscopic manifestations of discoid lupus erythematosus skin...
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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The transfer of bm12 lymphocytes into a C57BL/6 recipient is an established model of systemic lupus erythematosus. Here we describe how to initiate disease using this model and how to characterize T follicular helper cells, germinal center B cells and plasma cells by flow...
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin lesions are common and important features in many rheumatic diseases, and biopsy with pathological analysis plays a critical role in diagnosis. This article provides a detailed overview of the standardized skin biopsy procedure and, using discoid lupus erythematosus as an example, highlights the essential role of dermatopathology in diagnosing rheumatic...
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Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

The methodology for collecting high-density event-related potential data while patients with Alzheimer's disease perform a recognition memory task is reviewed. This protocol will include subject preparation, quality assurance, data acquisition, and data...
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In Silico Clinical Trials for Cardiovascular Disease09:09

In Silico Clinical Trials for Cardiovascular Disease

This protocol demonstrates the workflow of the SILICOFCM platform for automatically generating a parametric model of the left ventricle from patient-specific ultrasound images by applying a multi-scale electromechanical model of the heart. This platform enables in silico clinical trials intended to reduce real clinical trials and maximize positive therapeutic...
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Microfluidic Model to Mimic Initial Event of Neovascularization10:01

Microfluidic Model to Mimic Initial Event of Neovascularization

Here, we provide a microfluidic chip and an automatically controlled, highly efficient circulation microfluidic system that recapitulates the initial microenvironment of neovascularization, allowing endothelial cells (ECs) to be stimulated by high luminal shear stress, physiological level of transendothelial flow, and various vascular endothelial growth factor (VEGF) distribution...
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