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Related Concept Videos

A Technique to Generate an Adjuvant-Induced Arthritis Mouse Model03:29

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This video demonstrates a method to generate adjuvant-induced arthritis in a murine model. Complete Freund's adjuvant (CFA) is injected in the mouse ankle joint and periarticular areas. CFA activates the immune system, leading to neutrophil infiltration and exaggerated...
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A Cell-Based Therapy for Autoimmune Arthritis in a Murine Model03:52

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This video showcases a cell-based therapy for autoimmune arthritis in mice. iPSC-derived T regulatory cells expressing ovalbumin-specific receptors are injected with methylated bovine serum albumin (mBSA) emulsified in an adjuvant. Murine antigen-presenting cells (APCs) process and present the mBSA to T cells, prompting T cell activation and migration to the knee joint's synovial membrane. Subsequent injections involve mBSA alone in the left knee and a combination of mBSA and ovalbumin in the...
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Related Experiment Video

Updated: Jan 19, 2026

A Technique to Generate an Adjuvant-Induced Arthritis Mouse Model
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Pyogenic Arthritis.

Jenna E Holmen, Jumi Yi

    Pediatric Annals
    |September 11, 2019
    PubMed
    Summary
    This summary is machine-generated.

    Septic arthritis in children, often caused by Staphylococcus aureus, requires prompt diagnosis and treatment to avoid long-term issues. Treatment typically involves a 10-day to 4-week course of antibiotics, with shorter IV courses often sufficient.

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    Area of Science:

    • Pediatric infectious diseases
    • Pediatric rheumatology
    • Orthopedic infectious diseases

    Background:

    • Septic arthritis affects 4-10 per 100,000 children annually in developed nations, with a peak incidence around age 3.
    • Staphylococcus aureus is the most frequent pathogen, though microbial causes vary with patient age.
    • Timely diagnosis and intervention are crucial to prevent lasting joint damage and disability.

    Purpose of the Study:

    • To outline the epidemiology, diagnosis, and management of pediatric septic arthritis.
    • To emphasize the importance of early treatment to minimize sequelae.
    • To guide empiric antibiotic selection and duration based on age and likely pathogens.

    Main Methods:

    • Review of current literature and clinical guidelines on pediatric septic arthritis.
    • Analysis of epidemiological data regarding incidence and causative organisms.
    • Discussion of diagnostic criteria and therapeutic strategies, including antibiotic choice and duration.

    Main Results:

    • The incidence is 4-10 cases per 100,000 child-years, peaking at age 3.
    • Staphylococcus aureus is the predominant organism, but microbiology differs by age group.
    • Empiric therapy should target common pathogens, with treatment duration ranging from 10 days to 4 weeks.

    Conclusions:

    • Prompt diagnosis and treatment of pediatric septic arthritis are essential for favorable outcomes.
    • Antibiotic therapy, often initiated empirically, should be tailored to the patient's age and likely pathogens.
    • A short course of intravenous antibiotics is frequently adequate, but total treatment duration varies.