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Related Concept Videos

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals07:30

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This manuscript provides an innovative method for developing a biologic peripheral nerve interface termed the Muscle Cuff Regenerative Peripheral Nerve Interface (MC-RPNI). This surgical construct can amplify its associated peripheral nerve's motor efferent signals to facilitate accurate detection of motor intent and the potential control of exoskeleton devices.
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Olfactory ensheathing cells (OECs) are neural crest cells which allow growth of the primary olfactory neurons. This specific property can be used for cellular transplantation. We present here a model of cellular transplantation based on the use of OECs in a laryngeal nerve injury...
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Toluidine Blue Staining of Peripheral Nerve Sections: A Technique to Stain Myelinated Nerve Fibers For Peripheral Nerve Structure Visualization02:50

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Related Experiment Video

Updated: Jan 19, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
07:30

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

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Statin use and peripheral nerve function-A prospective follow-up study.

Toke de Koning Svendsen1,2,3, Thomas Krøigård1,2, Martin Wirenfeldt2,4

  • 1Department of Neurology, Odense University Hospital, Odense, Denmark.

Basic & Clinical Pharmacology & Toxicology
|September 11, 2019
PubMed
Summary
This summary is machine-generated.

This study found no clear group-level link between statin use and worsening peripheral nerve function. However, some individuals on statins showed decreased vibration sensitivity, suggesting potential effects in certain patients.

Keywords:
adverse effectscohort studynerve functionpolyneuropathyrisk factorsstatin

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Related Experiment Videos

Last Updated: Jan 19, 2026

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals
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Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Research

Background:

  • Statins are widely prescribed cholesterol-lowering drugs.
  • Potential adverse effects on peripheral nerves are a concern.

Purpose of the Study:

  • To investigate the association between statin initiation and changes in peripheral nerve function.
  • To assess the risk of peripheral nerve function deterioration in statin users compared to non-users.

Main Methods:

  • Prospective cohort study comparing statin users and never-users.
  • Assessed peripheral nerve function via nerve conduction studies, quantitative sensory testing, and skin biopsies.
  • Primary outcomes included five nerve function tests and intraepidermal nerve fibre density (IENFD).

Main Results:

  • No significant group-level deterioration in most nerve function tests observed.
  • A statistically significant increase in IENFD was noted in statin users compared to non-users (p=0.006).
  • Post hoc analysis revealed decreased vibration sensitivity in five statin users with neuropathy-like symptoms.

Conclusions:

  • Statin use was not clearly associated with increased peripheral nerve function deterioration at a group level.
  • Individual effects cannot be ruled out due to sample size limitations and post hoc findings.
  • Further research is warranted to explore potential individual susceptibility to statin-induced nerve changes.