Related Experiment Video
Updated: Jan 19, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics
Tobias C Walther1, Robert V Farese2
1Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA.
Abstract:
In a paper recently published in Science (Greenwood et al., 2019), Greenwood and colleagues now describe a fascinating example of how partitioning of a small lipophilic molecule into a phase-separated cellular constituent, the lipid droplet (LD), contributes to its antibacterial action against Mycobacterium tuberculosis.
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