Related Experiment Video

Updated: Jan 19, 2026

Hepatic Drug Clearance: Effect of Protein Binding
01:09

Hepatic Drug Clearance: Effect of Protein Binding

527

Vaspin is a novel target gene of hepatic CCAAT-enhancer-binding protein

Daisuke Aibara1, Kohei Matsuo1, Shigeru Yamano1

  • 1Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.

Gene
|September 11, 2019
PubMed

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Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
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