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Related Concept Videos

Sample Proportion and Population Proportion01:20

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Collecting samples or responses from an entire population takes significant time and effort, so a researcher collects responses from only a sample of that population. Suppose a study needs to collect information about a specific mobile application. After sample collection, the researcher analyzes the data and discovers that most individuals in the sample use that specific mobile application. The sample proportion measures the number of individuals in a sample who either use or don't use the...
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Focussed Ion Beam Milling and Scanning Electron Microscopy of Brain Tissue08:57

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Take a fixed section of mouse cortical brain tissue exhibiting neuronal axons and dendrites. The dendrites possess protrusions, known as dendritic spines, which form synapses with axons.Incubate the tissue with osmium-ferrocyanide, which binds to lipids, followed by another osmium application, which enhances structural contrast for imaging.Stain with a heavy metal compound that binds to macromolecules and enhances contrast.Dehydrate using increasing alcohol concentrations for resin...
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We use an aberration-corrected scanning transmission electron microscope to define single-digit nanometer patterns in two widely-used electron-beam resists: poly (methyl methacrylate) and hydrogen silsesquioxane. Resist patterns can be replicated in target materials of choice with single-digit nanometer fidelity using liftoff, plasma etching, and resist infiltration by...
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Related Experiment Video

Updated: Jan 19, 2026

Focussed Ion Beam Milling and Scanning Electron Microscopy of Brain Tissue
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Sparse proportional re-scanning with hadron beams.

Ugo Amaldi1, Caterina Cuccagna2, Alessandra Lo Moro3

  • 1TERA Foundation, CERN, 1211 Geneva, Switzerland.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|September 11, 2019
PubMed
Summary

Sparse proportional re-scanning significantly reduces treatment time in hadron therapy by optimizing spot visits. This novel technique offers substantial time savings for proton and carbon ion treatments, independent of target characteristics.

Keywords:
Hadron therapyParticle therapyProton dose deliveryRe-paintingRe-scanningSpot scanning

More Related Videos

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Particle Therapy

Background:

  • Hadron therapy utilizes spot scanning for precise dose delivery.
  • Current re-scanning techniques ensure uniform dose distribution, especially for moving organs, but increase treatment time.
  • Reducing treatment time is a critical area of research in particle therapy.

Purpose of the Study:

  • To introduce and evaluate a novel sparse proportional re-scanning technique.
  • To quantify the potential reduction in treatment time using this method.
  • To assess the applicability of sparse proportional re-scanning for proton and carbon ion therapy.

Main Methods:

  • A new technique, sparse proportional re-scanning, was defined.
  • This method was applied to 29 proton patient cases (54 fields).
  • A reduction factor was introduced and analyzed to quantify time savings.

Main Results:

  • Sparse proportional re-scanning reduces the number of scanned spots significantly.
  • The reduction factor was found to be dependent on the number of re-scans (N), with values of 2.8 ± 0.3 for N=5 and 3.6 ± 0.4 for N=12.
  • The reduction factor was independent of target shape, volume, and layer/grid distances.

Conclusions:

  • Sparse proportional re-scanning offers significant advantages in reducing treatment time for hadron therapy.
  • The technique is effective for both proton and carbon ion treatments.
  • The method shows promise for optimizing volumetric re-scanning protocols.