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Updated: Jan 19, 2026
Long Non-coding RNAs: Chromatin Modification, Cell Differentiation & Immune Response
Long non-coding RNAs and endometrial cancer
Hongyang Liu1, Junhu Wan2, Jie Chu2
1Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China.
Long non-coding RNAs (lncRNAs) are increasingly implicated in endometrial cancer (EC) progression, including tumorigenesis and metastasis. This review explores lncRNAs' roles in EC, highlighting their potential as diagnostic biomarkers and therapeutic targets.
Area of Science:
- Gynecologic Oncology
- Molecular Biology
- Cancer Research
Background:
- Endometrial cancer (EC) is a common gynecologic malignancy with unsatisfactory survival rates for advanced stages.
- Despite advances in treatment, novel therapeutic strategies are needed for EC.
- Long non-coding RNAs (lncRNAs) are emerging as critical regulators in various cancers.
Purpose of the Study:
- To review the known regulation and functional roles of lncRNAs in endometrial cancer.
- To discuss the potential of lncRNAs as diagnostic biomarkers for EC.
- To explore lncRNAs as potential therapeutic targets in EC treatment.
Main Methods:
- Literature review of studies on lncRNAs in endometrial cancer.
- Analysis of current evidence on lncRNA dysregulation in EC.
- Synthesis of findings on lncRNA involvement in EC tumorigenesis, metastasis, and chemoresistance.
Main Results:
- lncRNAs are frequently dysregulated in endometrial cancer.
- lncRNAs play significant roles in EC tumorigenesis, metastasis, and chemoresistance.
- Evidence suggests lncRNAs are closely linked to EC progression.
Conclusions:
- lncRNAs represent a promising area for understanding and treating endometrial cancer.
- Further research into lncRNA functions could lead to novel diagnostic and therapeutic strategies for EC.
- lncRNAs hold potential as biomarkers and therapeutic targets for endometrial cancer.
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