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Challenges in Developing Analytically Validated Laboratory-Derived Dietary Supplement Databases.

Joseph M Betz1, Catherine A Rimmer2, Leila G Saldanha1

  • 1Office of Dietary Supplements, National Institutes of Health, Bethesda, MD.

The Journal of Nutrition
|September 11, 2019
PubMed
Summary

The Dietary Supplement Ingredient Database (DSID) verifies supplement content, linking label claims to actual composition. Analytic chemistry challenges exist, especially for botanical supplements, impacting public health exposure assessments.

Keywords:
certified reference materialdietary supplementingredient databaselabellaboratory analysis

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Area of Science:

  • Analytical Chemistry
  • Nutritional Science
  • Public Health

Background:

  • Dietary supplement (DS) content verification is crucial as label claims may not reflect actual product composition.
  • Public health scientists and nutritionists need accurate data on DS constituents for exposure assessments.
  • Existing databases like the Dietary Supplement Label Database (DSLD) provide label information, but lack analytical verification.

Purpose of the Study:

  • To describe the challenges in creating analytically verified marketplace surveys of dietary supplement product content.
  • To highlight the importance of the Dietary Supplement Ingredient Database (DSID) for accurate dietary intake estimations.
  • To explore the feasibility and challenges of including botanical supplements in the DSID.

Main Methods:

  • Development of the Dietary Supplement Ingredient Database (DSID) for analytical verification of DS products.
  • Conducting surveys of various vitamin- and mineral-containing DSs.
  • Pilot project to assess the inclusion of botanical DS products in the DSID.

Main Results:

  • The DSID provides analytically derived values for supplement content, complementing the DSLD.
  • Surveys of vitamin and mineral supplements have been completed and results are available.
  • Challenges in selecting and analyzing botanical DS products for the DSID were identified.

Conclusions:

  • Analytically verified databases like DSID are essential for accurate dietary intake assessments in epidemiologic studies.
  • The DSID offers a crucial link between labeled content and actual exposure to supplement constituents.
  • Future expansion of the DSID, particularly for botanical supplements, faces significant analytical chemistry challenges requiring resources and time.