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Updated: Jan 19, 2026

Dietary Supplementation of Polyunsaturated Fatty Acids in Caenorhabditis elegans
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Why Americans Need Information on Dietary Supplements.

Johanna T Dwyer1, Paul M Coates1

  • 1Office of Dietary Supplements, National Institutes of Health, Bethesda, MD.

The Journal of Nutrition
|September 11, 2019
PubMed
Summary

Accessible dietary supplement (DS) databases are now available in the US, addressing a critical need for researchers studying supplement use and composition. This progress supports public health initiatives and regulatory oversight.

Keywords:
Dietary Supplement Health and Education Act (DSHEA)NIHOffice of Dietary Supplementsdatabasedietary supplement databasedietary supplementsnutrients

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Area of Science:

  • Nutrition Science
  • Public Health
  • Regulatory Science

Background:

  • Historically, a lack of open-access dietary supplement (DS) databases in the US hindered research on supplement use and composition.
  • Half of American adults use DSs, necessitating data for exposure assessment and public health.
  • Existing data gaps impacted the ability to estimate exposures and ensure public safety.

Purpose of the Study:

  • To describe the progress and challenges in developing and disseminating open-access DS databases.
  • To highlight the importance of DS information for government agencies and public health.
  • To outline future directions for DS research and data accessibility.

Main Methods:

  • Review of current developments in DS database initiatives.
  • Analysis of research efforts on DS quality, efficacy, and safety.
  • Examination of enhanced regulatory activities by federal agencies.
  • Survey data on DS use among the general and special US populations.

Main Results:

  • Development of open-access DS databases for public and commercial use.
  • Application of DS information to meet public health needs and inform regulatory actions.
  • Increased research on DS quality, efficacy, and safety.
  • Surveys reveal widespread DS use, underscoring the need for comprehensive data.

Conclusions:

  • Open-access DS databases are crucial for research, public health, and regulatory oversight.
  • Continued development and dissemination of DS databases are essential for advancing DS science.
  • Future efforts should focus on addressing challenges and expanding data accessibility.