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Related Experiment Video

Updated: Jan 19, 2026

Surgical Aortic Debanding: A Procedure to Study Left Ventricular Reverse Remodeling in Murine Model of Aortic Constriction
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Regression of Left Ventricular Mass in Athletes Undergoing Complete Detraining Is Mediated by Decrease in

Peter P Swoboda1, Pankaj Garg1, Eylem Levelt1

  • 1Department of Cardiovascular Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (P.P.S., P.G., E.L., D.A.B., A.Z.-N., A.J.R.F., G.J.F., P.G.C., L.A.B., C.E.S., E.D., J.P.G., S.P.).

Circulation. Cardiovascular Imaging
|September 12, 2019
PubMed
Summary

Detraining athletes showed reduced cardiac mass within one month, primarily due to intracellular changes, not extracellular. This athletic cardiac remodeling regresses quickly upon detraining.

Keywords:
athleteshypertrophymagnetic resonance imagingsports

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Area of Science:

  • Cardiology
  • Sports Medicine
  • Medical Imaging

Background:

  • Differentiating athletic cardiac remodeling from pathological hypertrophy is challenging.
  • Detraining is a diagnostic tool for physiological hypertrophy, indicated by regression.
  • The cellular basis of athletic cardiac remodeling during detraining requires clarification.

Purpose of the Study:

  • To determine if athletic cardiac remodeling involves intracellular or extracellular changes.
  • To assess the timeline of these changes during 1-3 months of detraining.
  • To investigate the role of cardiovascular magnetic resonance in evaluating these changes.

Main Methods:

  • Twenty-eight athletes undergoing detraining due to fractures were assessed.
  • Clinical assessment, ECG, and contrast-enhanced cardiovascular magnetic resonance were performed.
  • Follow-up assessments occurred at 1 and 3 months post-detraining initiation.

Main Results:

  • Left ventricular mass decreased significantly after 1 month of detraining (P<0.0001).
  • This reduction was mediated by a decrease in intracellular volume, with no change in extracellular volume.
  • Increased native T1 and extracellular volume fraction were observed after 1 month, with no further changes at 3 months.

Conclusions:

  • Athletic left ventricular hypertrophy regresses within 1 month of detraining.
  • Regression is driven by intracellular myocardial compartment changes, not extracellular.
  • Native T1 and extracellular volume fraction may aid in predicting detraining outcomes in further studies.