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Updated: Jan 19, 2026

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks
Published on: November 25, 2015
From chemical soup to computing circuit: transforming a contiguous chemical medium into a logic gate network by
Matthew Egbert1,2, Jean-Sébastien Gagnon1,3, Juan Pérez-Mercader1,4
1Department of Earth and Planetary Sciences, Harvard University, Cambridge, MA, USA.
Abstract:
It has been shown that it is possible to transform a well-stirred chemical medium into a logic gate simply by varying the chemistry's external conditions (feed rates, lighting conditions, etc.). We extend this work, showing that the same method can be generalized to spatially extended systems. We vary the external conditions of a well-known chemical medium (a cubic autocatalytic reaction-diffusion model), so that different regions of the simulated chemistry are operating under particular conditions at particular times. In so doing, we are able to transform the initially uniform chemistry, not just into a single logic gate, but into a functionally integrated network of diverse logic gates that operate as a basic computational circuit known as a full-adder.
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