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Updated: Jan 19, 2026

B Cell Activation on an Antigen-Coated Coverslip
Antigen-enabled facile preparation of MOF nanovaccine to activate the complement system for enhanced antigen-mediated
Yanxin Qi1, Lei Wang2, Huanhuan Guo3
1State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin 130022, P. R. China. leiwang@ciac.ac.cn ybhuang@ciac.ac.cn and Yanbian University Medical College, Yanji 133002, P. R. China. ningyij@hotmail.com.
Abstract:
Since current subunit vaccines are limited by a short half-life in vivo and weak immune responses when used alone without adjuvants, there is an unmet need for combing carriers with complement activation signals to interrupt outbreaks in real-time. Amino-functionalized zirconium-based MOFs (UiO-AM) could activate the complement system, which plays an important role in innate and adaptive immunity. Our data provide design principles for studies on complement activation as a safe vaccine carrier that can effectively enhance immune responses against antigens in vivo.
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