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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
Published on: July 19, 2013
Normal myocardial native T1 values in children using single-point saturation recovery and modified look-locker
Barbara Elisabeth Ursula Burkhardt1,2, Cristina Menghini1,2, Beate Rücker1,2
1Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zurich, Switzerland.
Insights
This study establishes normal pediatric myocardial T1 values using Smart1Map, finding longer T1 values compared to MOLLI. Septal T1 values were similar to total myocardial T1 values in children and adolescents.
Area of Science:
- Cardiovascular Imaging
- Magnetic Resonance Imaging
- Pediatric Cardiology
Background:
- T1 mapping quantifies diffuse myocardial processes like fibrosis and edema.
- Normal pediatric myocardial T1 values are limited with Modified Look-Locker Inversion Recovery (MOLLI) sequences.
- True T1 values are not available with Smart1Map, a single-point saturation recovery sequence.
Purpose of the Study:
- Establish normal pediatric myocardial T1 values using the Smart1Map sequence.
- Compare T1 values measured by Smart1Map with those obtained by MOLLI in children and adolescents.
- Investigate potential differences in T1 values across myocardial regions and their correlation with demographic factors.
Main Methods:
- Prospective cohort study involving 34 children and adolescents (aged 8-18 years).
- Utilized 1.5T MRI with both MOLLI and Smart1Map sequences for T1 measurements.
- Assessed mean T1 values in the left ventricular myocardium, interventricular septum, and blood pool across different short-axis slices.
Main Results:
- Smart1Map yielded significantly longer T1 values than MOLLI across all measured locations (P < 0.001).
- T1 values varied between basal and mid-ventricular slices for both myocardium and blood (P < 0.001).
- Myocardial T1 values showed no significant correlation with age, heart rate, or ejection fraction; septal T1 values did not differ from total myocardial T1 values.
Conclusions:
- Established normal pediatric native T1 values using the Smart1Map sequence.
- Demonstrated significant differences between Smart1Map and MOLLI T1 values in pediatric myocardium.
- Confirmed that septal T1 values are comparable to overall myocardial T1 values in children, excluding artifacts.
Background:
T1 mapping is useful to quantify diffuse myocardial processes such as fibrosis, edema, storage disorders, or hemochromatosis. Normal pediatric myocardial T1 values are scarce using modified Look-Locker inversion recovery (MOLLI) sequences and unavailable using Smart1Map, a single-point saturation recovery sequence that measures true T1 .
Purpose/Hypothesis:
To establish normal pediatric myocardial T1 values by Smart1Map and to compare them with T1 by MOLLI.
Study Type:
Prospective cohort study.
Subjects:
Thirty-four children and adolescents aged 8-18 years (14 males) without cardiovascular or inflammatory diseases.
Field Strength/Sequences:
1.5T, MOLLI, Smart1Map.
Assessment:
Mean T1 values of the left ventricular myocardium, the interventricular septum, and the blood pool were measured with MOLLI and Smart1Map in basal, mid-ventricular, and apical short axis slices.
Statistical Tests:
T1 values were compared between locations and methods by paired samples t-tests, Wilcoxon signed ranks test, repeated-measures analysis of variance (ANOVA), or Friedman's test. Pearson's correlation coefficient was calculated. For interobserver variability, intraclass correlation coefficients and coefficients of variation were calculated, and Bland-Altman analyses were performed.
Results:
T1 values were longer by Smart1Map than by MOLLI in all measured locations (myocardium: 1191-1221 vs. 990-1042 msec; all P < 0.001). T1 in basal vs. mid-ventricular slices differed both by MOLLI and by Smart1Map for myocardium and for blood (all P < 0.001). Myocardial T1 did not correlate with age, heart rate, right or left ventricular ejection fraction (all P > 0.05) by either method. Septal vs. total myocardial T1 values in each slice did not differ by MOLLI (basal P = 0.371; mid-ventricular P = 0.08; apical P = 0.378) nor by Smart1Map (basal P = 0.056; mid-ventricular P = 0.918; apical P = 0. 392), after artifacts had been carefully excluded.
Data Conclusion:
We established pediatric normal native T1 values using the Smart1Map sequence and compared the results with T1 mapping with MOLLI. Septal T1 values did not differ from total myocardial T1 values in each of the myocardial slices.
Level Of Evidence:
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:897-903.
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