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Updated: Jan 19, 2026
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Proteome-Wide Epstein-BarrVirus Analysis of Peptide Sharing with Human Systemic Lupus Erythematosus Autoantigens
1Department of Biosciences, Biotechnologies, and Biopharmaceutics, University of Bari, Italy.
Background:
Although cross-reactions between Epstein-Barr virus (EBV) and human systemic lupus erythematosus (SLE) autoantigens occur, a complete analysis of the potential EBV peptide cross-reactome has not been performed.
Objectives:
To analyze the whole EBV proteome searching for peptides common to SLE-related proteins and endowed with an immunological potential.
Methods:
Fifty-one SLE-related proteins were analyzed for hexapeptide sharing with EBV proteome using publicly available databases.
Results:
An extremely high number of hexapeptides are shared between 34 human SLE autoantigens and EBV proteins. The peptide sharing mostly occurs with complement components C4 and Interleukin-10 (IL-10).
Conclusions:
This study thoroughly describes the EBV vs. SLE autoantigens peptide overlap and powerfully supports cross-reactivity as a major mechanism in EBV-associated SLE etiopathogenesis.
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