Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A Platelet's Guide to Synovitis.

Giacomo Cafaro¹, Elena Bartoloni¹, Alessia Alunno¹

¹Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy.

The Israel Medical Association Journal : IMAJ

|September 12, 2019

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pain and its relationship with fatigue in Sjögren disease: an Italian single-centre experience.

EULAR rheumatology open·2026

Same author

Global perspectives on rheumatology training: insights from the EULAR 2025 EMEUNET Presents session.

EULAR rheumatology open·2026

Same author

Healthcare providers' awareness and knowledge of recommendations on cardiovascular risk management in people with rheumatic and musculoskeletal diseases: a survey study.

EULAR rheumatology open·2026

Same author

Long-term remission and monocyclic course in Still's disease patients starting canakinumab early: data from the international AIDA network registry.

Seminars in arthritis and rheumatism·2026

Same author

Defining interstitial lung disease related to idiopathic inflammatory myopathies: a systematic review protocol of the Myositis Clinical Trial Consortium (MCTC).

Systematic reviews·2026

Same author

Italian Olfactory Identification Test in Systemic Lupus Erythematosus: Association of Olfactory Impairment With Chronic Damage and Anti-β<sub>2</sub>-Glycoprotein I Antibodies.

ACR open rheumatology·2026

Platelets significantly contribute to rheumatoid arthritis pathogenesis by influencing immune responses and inflammation, potentially before disease onset. Their role in autoimmunity and joint damage highlights platelets as future therapeutic targets.

Area of Science:

Immunology
Rheumatology
Cell Biology

Background:

Platelets modulate immune responses and inflammation, implicating them in chronic inflammatory joint diseases like rheumatoid arthritis.
Platelet involvement may precede clinical disease onset, contributing to immune system tolerance loss and autoimmunity induction.

Purpose of the Study:

To elucidate the multifaceted role of platelets in the pathogenesis of rheumatoid arthritis.
To explore platelets as potential therapeutic targets for inflammatory joint diseases.

Main Methods:

Review of existing literature on platelet function in autoimmunity and inflammation.
Analysis of platelet interactions with immune cells (innate immunity, T cells) and synovial fibroblasts.

Main Results:

Related Experiment Videos

Platelets interact with key immune cells, promoting inflammation in the synovium.
Platelet activity drives fibroblast activation, migration, and proliferation, leading to joint damage.

Conclusions:

Platelets are pivotal in rheumatoid arthritis pathogenesis, from early immune dysregulation to joint destruction.
Despite study challenges, platelets represent promising future therapeutic targets for rheumatoid arthritis and related conditions.