Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis10:33

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis

3.1K
This protocol outlines the steps for inducing Primed Mycobacterial Uveitis (PMU) in mice. This method outlines the steps to help produce reliable and robust ocular inflammation in the mouse model system. Using this protocol, we generated uveitic eyes and uninflamed fellow eyes from single animals for further evaluation with immunologic, transcriptomic, and proteomic...
3.1K
A Murine Model of Primed Mycobacterial Uveitis to Study Post-Infectious Uveitis04:00

A Murine Model of Primed Mycobacterial Uveitis to Study Post-Infectious Uveitis

611
This video demonstrates a method to generate a mouse model of primed mycobacterial uveitis (PMU) for studying post-infectious uveitis. Upon induction of PMU by intravitreal injection of heat-killed Mycobacterium tuberculosis in a mouse previously immunized with the same immunogen, the progression of chronic inflammation in the eye is analyzed using imaging and histopathological...
611
The Evidence for Evolution02:55

The Evidence for Evolution

47.6K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
47.6K
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

6.0K
In this report we present a protocol that allows the investigator to generate a mouse model of intraocular uveitis. More commonly referred to as experimental autoimmune uveitis (EAU), this established model captures many aspects of human disease. Herein, we will describe how to induce and monitor disease progression using several readouts.
6.0K
Optical Coherence Tomography Imaging for Assessing Uveitis in a Mouse Model03:12

Optical Coherence Tomography Imaging for Assessing Uveitis in a Mouse Model

734
This video demonstrates an in vivo imaging technique for detecting and quantifying eye inflammation in a mouse model of post-infectious uveitis. The technique, known as optical coherence tomography (OCT), generates high-resolution cross-sectional images of the eye for assessing disease...
734
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

1.3K
This article describes RUGGED (Retrieval Under Graph-Guided Explainable disease Distinction), which integrates Large Language Model (LLM) inference with Retrieval-Augmented Generation (RAG). It draws evidence from expert-curated biomedical knowledge bases and peer-reviewed biomedical publications to synthesize new knowledge from up-to-date information, identify explainable and actionable predictions, and pinpoint promising directions for hypothesis-driven...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 Cases.

The Journal of rheumatology·2026
Same author

Diagnosis, treatment and monitoring of pediatric Behçet's disease: Systematic literature review informing the ISSAID/PRES recommendations.

Autoimmunity reviews·2026
Same author

Identifying outcome measures for clinical trials in juvenile idiopathic arthritis associated uveitis for the MIWGUC proposal: a scoping review to create domains from existing outcome measures.

Pediatric rheumatology online journal·2026
Same author

Emergency in pediatric rheumatology: a narrative review.

Frontiers in medicine·2026
Same author

What is the best way to plan a 12-month clinical drug trial in JIA associated uveitis?

Expert review of clinical immunology·2026
Same author

Calcinosis Cutis and Delayed-Onset Myositis in a Case of Suspected Localized Scleroderma: A Diagnostic and Therapeutic Challenge.

Pediatric dermatology·2026

Related Experiment Video

Updated: Jan 19, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.1K

Evidence-Based Treatment for Uveitis.

Lisa Gamalero1, Gabriele Simonini1, Giovanna Ferrara1

  • 1Department of Pediatric Rheumatology, Meyer Children University Hospital, Florence, Italy.

The Israel Medical Association Journal : IMAJ
|September 12, 2019
PubMed
Summary

Non-infectious uveitis, an inflammatory eye condition, requires prompt diagnosis and treatment. Adalimumab shows proven efficacy in both adults and children, offering a key biologic treatment option.

More Related Videos

A Murine Model of Primed Mycobacterial Uveitis to Study Post-Infectious Uveitis
04:00

A Murine Model of Primed Mycobacterial Uveitis to Study Post-Infectious Uveitis

611
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

6.0K

Related Experiment Videos

Last Updated: Jan 19, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

3.1K
A Murine Model of Primed Mycobacterial Uveitis to Study Post-Infectious Uveitis
04:00

A Murine Model of Primed Mycobacterial Uveitis to Study Post-Infectious Uveitis

611
Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

6.0K

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Immunology

Background:

  • Non-infectious uveitis is a serious inflammatory eye condition affecting all ages, potentially causing vision loss.
  • It can stem from systemic autoimmune diseases or be idiopathic, necessitating specialist collaboration.
  • Prompt diagnosis and a step-ladder treatment approach are crucial to manage inflammation and prevent complications.

Purpose of the Study:

  • To review current evidence-based treatments for non-infectious uveitis in pediatric and adult patients.
  • To focus on the efficacy and application of biologic response modifier treatments.
  • To highlight the importance of a structured treatment approach.

Main Methods:

  • Review of current evidence-based treatments for non-infectious uveitis.
  • Analysis of multicenter studies on biologic agents, including adalimumab.
  • Examination of treatment efficacy in pediatric and adult populations.

Main Results:

  • Adalimumab has demonstrated significant efficacy in treating non-infectious uveitis in adults (VISUAL I-III studies).
  • The SYCAMORE and ADJUVITE studies confirmed adalimumab's effectiveness in pediatric patients.
  • Evidence for other biologic agents in non-infectious uveitis remains limited.

Conclusions:

  • Adalimumab is an effective biologic treatment for non-infectious uveitis in both children and adults.
  • A step-ladder approach, starting with less aggressive treatments, is recommended.
  • Further research is needed for other biologic agents in managing this condition.