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Related Concept Videos

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation07:13

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Mice with acquired hypoparathyroidism would be useful for studying novel drug therapies for hypoparathyroidism. Two procedures to create such mice are demonstrated. The GFP-PTX mouse is generated by surgical parathyroidectomy guided by green fluorescing parathyroid glands. A second, non-surgical approach is based on parathyroid-specific expression of the diphtheria toxin...
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An animal model of acquired hypoparathyroidism (HypoPT) is crucial to understanding how HypoPT affects mineral ion homeostasis and to verify the effectiveness of novel treatments. Here, a technique is presented to generate an acquired hypoparathyroidism (AHypoPT) rat model by parathyroidectomy (PTX) using carbon...
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Related Experiment Video

Updated: Jan 19, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

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Minimal Invasive Radioguided Ectopic Parathyroidectomy in Upper Mediastinum

Zehra Pınar Koç1, Turgut Karlıdağ2, Pelin Özcan Kara1

  • 1Mersin University Faculty of Medicine, Department of Nuclear Medicine, Mersin, Turkey

Molecular Imaging and Radionuclide Therapy
|September 12, 2019
PubMed
Summary

A minimally invasive radioguided surgery successfully treated a persistent ectopic parathyroid adenoma in the upper mediastinum, even after multiple prior neck explorations. This approach offers a solution for complex cases of hyperparathyroidism.

Keywords:
Hyperparathyroidismadenomaminimally invasiveradioimmunodetection

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Nuclear Medicine

Background:

  • Ectopic parathyroid adenomas can present diagnostic and surgical challenges, particularly when located in the upper mediastinum.
  • Multiple previous neck explorations complicate the management of persistent or recurrent hyperparathyroidism.
  • Locating and resecting ectopic parathyroid tissue requires precise surgical techniques.

Purpose of the Study:

  • To present a case of successful surgical management of a persistent upper mediastinal ectopic parathyroid adenoma.
  • To highlight the utility of a radioguided minimal invasive approach in a complex surgical scenario.
  • To demonstrate an effective strategy for patients with a history of multiple neck surgeries.

Main Methods:

  • Utilized a radioguided surgery technique for localization and resection.
  • Employed a minimally invasive surgical approach.
  • Focused on a patient with a history of multiple prior neck explorations and a known ectopic parathyroid adenoma.

Main Results:

  • Successful resection of the upper mediastinal ectopic parathyroid adenoma was achieved.
  • The radioguided minimal invasive approach facilitated precise localization and removal.
  • The patient experienced a positive outcome following the intervention.

Conclusions:

  • Radioguided minimal invasive surgery is a viable and effective option for managing persistent ectopic parathyroid adenomas, especially in challenging cases.
  • This technique can overcome difficulties associated with multiple previous neck explorations.
  • Successful treatment of ectopic parathyroid adenomas can be achieved with advanced surgical strategies.