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Updated: Jan 19, 2026

First Pass Effect
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First Pass Effect

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Impact of Pharmacy School Characteristics on NAPLEX First-time Pass Rates

Jennifer S Williams1, Christina A Spivey1, Tracy M Hagemann1

  • 1University of Tennessee College of Pharmacy, Memphis, Tennessee.

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First Pass Effect01:12

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Presystemic elimination, or the first-pass effect, is the metabolism of drugs that reduces their effective concentration at the site of action. Apart from the first-pass effect, the systemic bioavailability of the drug is also reduced by other factors, including incomplete absorption or chemical degradation of drugs.
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