Related Concept Videos

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats08:57

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

We describe two tactile sensory testing methods for acute or chronic periods of spinal cord injury in rats. These validated procedures can detect the development and maintenance of allodynia-like...
24.3K
Induction of Neuropathic Pain in a Rat Model by Constriction of the Infraorbital Nerve04:39

Induction of Neuropathic Pain in a Rat Model by Constriction of the Infraorbital Nerve

Source: Deseure, K., et al. Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain. J. Vis. Exp. (2015).This video demonstrates a method to induce neuropathic pain in a rat model by constricting the infraorbital nerve. After exposing the infraorbital nerve and tying ligatures to constrict it, the immune response at the injury site increases the excitability of neighboring neurons, which transmit pain signals to the...
514
Modulation of Chronic Pain Using Multicolumn Paddle Lead Spinal Cord Stimulation02:20

Modulation of Chronic Pain Using Multicolumn Paddle Lead Spinal Cord Stimulation

Source: Remacle, T., et al. Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation. J. Vis. Exp. (2018)This video demonstrates the method of using multicolumn paddle lead spinal cord stimulation to manage chronic lower back pain in Failed back surgery syndrome (FBSS) patients. The pre-implanted lead delivers targeted electrical pulses that activate non-painful sensory pathways, interrupting pain signals and reducing pain...
255
Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

This paper presents a method that uses spinal cord stimulation with a multicolumn lead to treat neuropathic low back pain in failed back surgery...
15.1K
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Neuropathic pain is a consequence of a lesion or disease affecting the somatosensory system. The “cuff model” of neuropathic pain in mice consists of the implantation of a polyethylene cuff around the main branch of the sciatic nerve. Mechanical allodynia is tested using von Frey...
49.3K
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain10:52

Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain

This manuscript describes a rodent model to study trigeminal neuropathic pain. The methods described include surgical procedures to perform a chronic constriction injury of the rat’s infraorbital nerve and the post-surgical behavioral tests to measure the changes in spontaneous and evoked behavior that are indicative of persistent pain and allodynia.
20.7K