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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Drug Excretion: Miscellaneous Routes01:10

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Drug excretion involves various organs, including the liver, intestines, skin, and eyes. In the case of drugs or toxins, they can be actively secreted into bile by transporters in the hepatocyte's canalicular membrane. These substances enter the GI tract during digestion and may be reabsorbed into the body from the intestine. This process, known as enterohepatic recycling, can significantly prolong the presence and effects of a substance in the body. To interrupt this cycle, specific...
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Factors Affecting Drug Distribution: Miscellaneous Factors01:19

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Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
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Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters00:54

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The noncompartmental approach is a widely used method in pharmacokinetics to assess drugs' behaviors in the body. It considers several factors, including clearance, bioavailability, and total volume of distribution.
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Phase II Reactions: Miscellaneous Conjugation Reactions01:19

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Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
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Updated: Jan 19, 2026

Drug Delivery: Miscellaneous Routes
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Miscellaneous Perianal Afflictions.

Gonzalo F Hagerman1, Jorge Silva-Velazco1, Juan Francisco Molina-Lopez1

  • 1Department of Surgery, ABC Medical Center, Mexico City, Mexico.

Clinics in Colon and Rectal Surgery
|September 12, 2019
PubMed
Summary
This summary is machine-generated.

This article reviews common perianal skin conditions including hidradenitis suppurativa and lichen planus. It offers guidance on recognizing and managing these diverse dermatological issues in the perianal area.

Keywords:
calcinosis cutihidradenitis suppurativaintertrigo and seborrheic keratosislichen planuslichen sclerosispyogenic granuloma

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Last Updated: Jan 19, 2026

Drug Delivery: Miscellaneous Routes
01:22

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01:10

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Factors Affecting Drug Distribution: Miscellaneous Factors
01:19

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957

Area of Science:

  • Dermatology
  • Gastroenterology

Background:

  • The perianal region is susceptible to a variety of complex dermatological conditions.
  • Accurate diagnosis and timely management are crucial for patient well-being.

Purpose of the Study:

  • To provide a comprehensive overview of key perianal dermatoses.
  • To enhance the recognition and management strategies for these conditions.

Main Methods:

  • Literature review of common perianal skin conditions.
  • Synthesis of current diagnostic and therapeutic approaches.

Main Results:

  • Detailed descriptions of hidradenitis suppurativa, lichen planus, lichen sclerosus, calcinosis cutis, pyogenic granuloma, intertrigo, and seborrheic keratosis.
  • Emphasis on characteristic clinical presentations and differential diagnoses.
  • Outline of evidence-based management protocols.

Conclusions:

  • Effective management of perianal dermatoses requires a systematic approach.
  • Early recognition and appropriate treatment can significantly improve outcomes for patients presenting with these conditions.