Frontiers of Knowledge and Public Health

This article describes RUGGED (Retrieval Under Graph-Guided Explainable disease Distinction), which integrates Large Language Model (LLM) inference with Retrieval-Augmented Generation (RAG). It draws evidence from expert-curated biomedical knowledge bases and peer-reviewed biomedical publications to synthesize new knowledge from up-to-date information, identify explainable and actionable predictions, and pinpoint promising directions for hypothesis-driven...

A computational protocol, CaseOLAP LIFT, and a use case are presented for investigating mitochondrial proteins and their associations with cardiovascular disease as described in biomedical reports. This protocol can be easily adapted to study user-selected cellular components and...

The Production Possibility Frontier (PPF) illustrates the maximum combination of two goods or services an economy can produce given its available resources and level of technology. It serves as a visual representation of the trade-offs between different production options.
The PPF assumes that resources are fixed and fully employed and technology remains constant. Any point on the curve represents a combination of goods that fully utilizes available resources.
Points inside the curve indicate...

The Edgeworth Box illustrates all possible ways to allocate a fixed amount of labor and capital between two firms—one producing wheat and the other producing cotton. Each point within the box represents a specific allocation of these inputs between the two firms. Among these points, the contract curve highlights all Pareto-efficient allocations, where no reallocation of labor or capital can increase one firm’s output without reducing the other’s. This condition defines Pareto efficiency,...

The goal of this protocol is to enable non-dental professionals to assess oral health status for research or health-screening purposes. Aspects assessed include lips, tongue, soft and hard tissues, natural and artificial teeth, oral cleanliness, plaque, swallowing, and impact of oral health on quality of...

Public goods are services or resources provided primarily by the government because private companies often do not have an incentive to supply them at socially efficient levels. These goods are both non-excludable, meaning that people cannot be prevented from using them, and non-rivalrous, meaning that one person's use does not reduce their availability for others.
If private firms are unable to economically prevent multiple, non-paying consumers from consuming their goods, then some...