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Updated: Jan 19, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
Using Implementation Frameworks to Provide Proactive Physical Therapy for People With Parkinson Disease: Case Report
Miriam R Rafferty1, Jillian MacDonald2, Alexandria Byskosh3
1Shirley Ryan AbilityLab Illinois; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, 355 E Erie St, 19th Floor Strength and Endurance Lab, Chicago, IL 60611 (USA); and Department of Psychiatry and Behavioral Science, Feinberg School of Medicine, Northwestern University.
A proactive physical therapy (PAPT) approach for Parkinson disease (PD) patients increased exercise participation and improved physical and emotional well-being. This early intervention model, utilizing implementation frameworks, supports long-term independent exercise maintenance.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Public Health
Background:
- European guidelines advocate for early physical therapy in Parkinson disease (PD) for education and intervention.
- Current practice often delays physical therapy until gait and balance issues arise, missing a crucial window for proactive care.
Purpose of the Study:
- To present the application of a proactive physical therapy (PAPT) approach for individuals with Parkinson disease (PD).
- To utilize implementation frameworks to guide the process, identify success factors, and evaluate the implementation of PAPT.
Main Methods:
- The PAPT program targeted individuals with PD before significant mobility decline in an outpatient setting.
- Implementation utilized the Knowledge-to-Action and Consolidated Framework for Implementation Research.
- The RE-AIM framework and mixed methods were employed for program evaluation.
Main Results:
- In the first year, 20 participants completed the 6-month PAPT program evaluation.
- Regular participation in aerobic, strengthening, and flexibility exercises approximately doubled; balance activity engagement increased significantly.
- Participants reported a median of 140 minutes of weekly aerobic exercise and experienced physical and emotional benefits.
Conclusions:
- Implementation frameworks facilitated the successful application and evaluation of a PAPT delivery model.
- The PAPT approach effectively enhanced and sustained independent exercise participation in individuals with Parkinson disease.
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