Terbinafine-loaded branched PLGA-based cationic nanoparticles with modifiable properties

Area of Science:

• Polymer chemistry
• Nanotechnology
• Pharmaceutical sciences

Background:

• Topical terbinafine formulations are preferred for localized fungal infections.
• Polymeric nanoparticles (NPs) offer advanced strategies for topical antifungal drug delivery.

Purpose of the Study:

• To develop and characterize terbinafine-loaded polymeric nanoparticles (NPs) using novel PLGA derivatives.
• To optimize NP properties for enhanced drug loading, mucoadhesion, and sustained release.

Main Methods:

• Synthesis of branched PLGA derivatives with controlled properties.
• Nanoprecipitation method for compounding terbinafine-loaded NPs.
• Characterization of NP size, zeta potential, PDI, drug loading, and release kinetics.
• Agar-well diffusion assay to evaluate antimicrobial activity.

Main Results:

• NPs with sizes ranging from 100 to 600 nm were formulated, with hydrophobicity and polyester concentration as key factors.
• Stable nanosuspensions were achieved (zeta potential >25 mV, PDI <0.2).
• Terbinafine base incorporation increased drug loading and delayed release; cationic surfactant enhanced mucoadhesion.
• All formulations demonstrated prolonged, sustained terbinafine release over several days and significant antimicrobial potential.

Conclusions:

• Tailored PLGA-based NPs provide an effective platform for topical terbinafine delivery.
• Optimized NP characteristics ensure enhanced drug loading, sustained release, and improved mucoadhesion for localized antifungal therapy.
• These NPs show promise for managing topical fungal infections with improved efficacy and duration.