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Updated: Jan 19, 2026

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

Dysbiosis: from fiction to function.

Connor R Tiffany¹, Andreas J Bäumler¹

¹Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis California.

American Journal of Physiology. Gastrointestinal and Liver Physiology

|September 12, 2019

Summary

Microbial community imbalance, or dysbiosis, is linked to human illness. A new framework using ecological and immunological principles offers a functional definition for dysbiosis, guiding future research into its mechanisms.

Keywords:

dysbiosis homeostasis microbiome microbiota

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Functional Groups and Types of Organic Compounds

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Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Functional Reconstitution and Channel Activity Measurements of Purified Wildtype and Mutant CFTR Protein

Published on: March 9, 2015

Area of Science:

Microbiology
Immunology
Ecology

Background:

Advances in data collection reveal links between host-associated microbial community imbalance (dysbiosis) and human illnesses.
Dysbiosis is a central concept for understanding the human microbiota's role in health and disease.
Defining dysbiosis solely by cataloging microbial species is problematic.

Purpose of the Study:

To provide a functional definition for dysbiosis.
To propose a theoretical framework for microbiota research incorporating the germ-organ concept, ecological assumptions, and immunological principles.

Main Methods:

Literature review and theoretical synthesis.
Integration of ecological and immunological principles.
Application of the germ-organ concept to microbiota research.

Main Results:

A theoretical framework for microbiota research is proposed.
This framework offers a functional definition of dysbiosis.
The framework highlights the importance of immune mechanisms in maintaining microbial balance.

Conclusions:

A functional definition of dysbiosis can be achieved through an integrated theoretical framework.
Future research should focus on the mechanistic underpinnings of dysbiosis.
Weakening of immune mechanisms is often implicated in dysbiosis.