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Related Concept Videos

Vagus Nerve Stimulation via Chronically Implanted Peripheral Nerve Cuff Electrodes in Rats02:00

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Source: Sanchez, C. A., et al. Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats. J. Vis. Exp. (2020).This video demonstrates vagus nerve stimulation in an awake rat. A rat with an implanted chronic peripheral nerve cuff electrode and trained in a lever press task is connected to a stimulus generator via an implanted head cap. The vagus nerve is stimulated immediately after each successful lever press, resulting in the expansion of the motor...
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Existing approaches for constructing chronically implantable peripheral nerve cuff electrodes for use in small rodents often require specialized equipment and/or highly trained personnel. In this protocol we demonstrate a simple, low-cost approach for fabricating chronically implantable cuff electrodes, and demonstrate their effectiveness for vagus nerve stimulation (VNS) in...
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Related Experiment Video

Updated: Jan 19, 2026

Vagus Nerve Stimulation via Chronically Implanted Peripheral Nerve Cuff Electrodes in Rats
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Vagus Nerve Stimulation via Chronically Implanted Peripheral Nerve Cuff Electrodes in Rats

Published on: August 29, 2025

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Fascicle specific targeting for selective peripheral nerve stimulation.

Cynthia K Overstreet1, Jonathan Cheng1,2, Edward W Keefer1

  • 1Nerves Incorporated, Dallas TX, United States of America.

Journal of Neural Engineering
|September 12, 2019
PubMed
Summary

Targeting electrodes to specific nerve fascicles creates selective neural interfaces. This approach improves sensory feedback and motor control for neuroprosthetics, minimizing side effects.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Neural Engineering

Background:

  • Electrical stimulation typically activates neurons uniformly, leading to unintended side effects like imprecise sensory perception and muscle twitches.
  • Current methods for neural interfaces often lack selectivity, limiting their effectiveness in neuroprosthetic applications.

Purpose of the Study:

  • To investigate the benefits of placing electrodes within specific fascicles of peripheral nerves for creating selective neural interfaces.
  • To develop and evaluate fascicle-specific interfacing techniques for bidirectional neuroprosthetic devices.

Main Methods:

  • Chronic electrodes (FAST-LIFE arrays) were surgically implanted into individual fascicles of the ulnar and median nerves in human subjects.
  • Functional testing identified sensory and motor fiber composition within fascicles.
  • Characterization of evoked sensations and stimulation parameters over a 90-180 day period.

Main Results:

  • FAST-LIFE arrays enabled selective and chronic electrical stimulation of individual peripheral nerve fascicles.
  • Stimulation of sensory fascicles evoked distinct tactile and cutaneous sensations, while motor fascicles produced proprioceptive sensations.
  • Stimulation thresholds and strength-duration time constants varied between sensory and motor fascicles.

Conclusions:

  • Placing electrodes within fascicles creates highly selective and stable neural interfaces.
  • This fascicle-specific approach allows precise targeting of nerve fibers for specific functions or body regions.
  • Fascicle-specific interfacing holds significant potential for enhancing neuromodulation therapies and neuroprosthetics.