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Related Concept Videos

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion03:22

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Local anesthetic thoracoscopy (LAT) is essential for diagnosing recurrent, undiagnosed pleural effusion when a guideline-based workup fails to provide a specific cause. LAT can be performed as a day-case procedure by chest physicians. Here, we present a step-by-step approach for a successful and safe...
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Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
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Pleural Effusion II: Symptoms and Management01:28

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Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
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A thoracic oncology database was developed to serve as a comprehensive repository for clinical and laboratory data for the purposes of translational research. The database will serve translational cancer researchers within the Thoracic Oncology Research Program. This database is adaptable to other cancer models, as well as other human...
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Related Experiment Video

Updated: Jan 19, 2026

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
03:22

Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion

Published on: November 10, 2023

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Pulmonary Infarction with Pleural Effusion - Pathologic Surprise in the Oncological Patient.

Pvh Botianu, A M Botianu, E S Ianosi

    Chirurgia (Bucharest, Romania : 1990)
    |September 13, 2019
    PubMed
    Summary

    This case highlights diagnostic challenges in oncology patients with pleural effusion. Early surgical intervention for suspected malignancy, even with unusual findings like eosinophils, led to a favorable outcome, avoiding unnecessary chemotherapy.

    Keywords:
    cancerpulmonaryinfarctionrecurrentpleuraleffusion

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    Area of Science:

    • Oncology
    • Pulmonology
    • Thoracic Surgery

    Background:

    • A 49-year-old female with a history of breast cancer presented with recurrent pleural effusion unresponsive to medical treatment.
    • Initial pleural fluid analysis showed high protein, normal glucose, elevated LDH, and eosinophilia, with no malignant cells detected.

    Observation:

    • Computed tomography revealed a loculated pleural effusion and thickened pleura, suspicious for malignancy.
    • Intraoperative findings included a loculated effusion and multiple subpleural pulmonary nodules, presumed to be metastases.

    Findings:

    • Pathological examination of pleural tissue showed inflammation without atypia; pulmonary resection specimens revealed infarction, not malignancy.
    • Despite normal initial coagulation tests, detailed analysis was lacking. Postoperative ultrasounds did not identify a cause for infarction.

    Implications:

    • This case underscores the diagnostic complexities of pleural effusions in cancer survivors.
    • Aggressive surgical management, despite ambiguous findings, proved beneficial, averting ineffective chemotherapy and potential suppurative complications.