Rebuttal From Drs Koenig and Tsegaye

Here, we describe a methodology to obtain a pure population of human myoblasts from adult muscle tissue. These cells are used to study in vitro skeletal muscle differentiation and, in particular, to study proteins involved in Ca2+...

Source: Laboratories of Nicholaus Noles and Judith Danovitch—University of Louisville
Humans are different from other animals in many ways, but perhaps the most important differentiating factor is their ability to use language. Other animals can communicate and even understand and use language in limited ways, but trying to teach human language to a chimp or a dog takes a great deal of time and effort. In contrast, young humans acquire their native language easily, and they learn...

Source: Laboratories of Nicholaus Noles and Judith Danovitch—University of Louisville
One of the goals of the modern education system is to teach children mathematical literacy. They are taught to add, subtract, multiply, and divide, and this base knowledge is used to support learning about geometry, algebra, calculus, physics, and statistics. School-aged children usually acquire these skills in formal educational settings, but the foundation of mathematical understanding is developed...

Here we describe optical acquisition and characterization of action potentials from induced pluripotent stem cell derived cardiomyocytes using a high-speed modular photometry...

Presented here is a protocol to generate engineered connective tissues for a parallel culture of 48 tissues in a multi-well plate with double poles, suitable for mechanistic studies, disease modeling, and screening applications. The protocol is compatible with fibroblasts from different organs and species and is exemplified here with human primary cardiac...

Cells that can differentiate into a variety of cell types, known as stem cells, are at the center of one of the most exciting fields of science today. Stem cell biologists are working to understand the basic mechanisms that regulate how these cells function. These researchers are also interested in harnessing the remarkable potential of stem cells to treat human diseases.
Here, JoVE presents an introduction to the captivating world of stem cell biology. We begin with a timeline of landmark...