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hs-CRP Is Associated With Incident Diabetic Nephropathy: Findings From the Jackson Heart Study

Satyesh K Sinha1,2, Susanne B Nicholas3, Jung Hye Sung4

  • 1Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA satyeshsinha@cdrewu.edu sunicholas@mednet.ucla.edu.

Diabetes Care
|September 13, 2019
PubMed

Insights

High levels of high-sensitivity C-reactive protein (hs-CRP) may increase the risk of developing diabetic nephropathy (DN) in African Americans. This inflammation marker is linked to a higher incidence of DN in this population.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Endocrinology

Background:

  • Diabetic nephropathy (DN) disproportionately affects African Americans (AA).
  • High-sensitivity C-reactive protein (hs-CRP) is linked to prevalent DN, but its role in incident DN among AA is not well understood.

Purpose of the Study:

  • To investigate the association between hs-CRP levels and the incidence of DN in African Americans.

Main Methods:

  • Longitudinal analysis of 4,043 Jackson Heart Study participants over a median follow-up of 7.8 years.
  • Incident DN defined by urinary albumin-to-creatinine ratio (ACR) or dialysis/transplantation in participants with type 2 diabetes.
  • Cox proportional hazards regression used to analyze hs-CRP tertiles and DN incidence, adjusting for covariates.

Main Results:

  • Participants who developed DN had higher baseline hs-CRP, age, glucose, triglycerides, ACR, blood pressure, waist circumference, and diabetes duration.
  • The incidence rate of DN was 7.9% over the follow-up period.
  • High hs-CRP levels (highest tertile) were associated with a 2.34-fold increased hazard of incident DN compared to the lowest tertile.

Conclusions:

  • Inflammation, indicated by hs-CRP, may be associated with incident DN in African Americans.
  • Further research is needed to confirm this association and understand its underlying mechanisms.
Abstract

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