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Updated: Jan 19, 2026

Appendicitis-I: Introduction
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Appendicitis-I: Introduction

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Simultaneous acute appendicitis in identical twin boys

Mark L Kovler1, Eric B Jelin1

  • 1Division of General Pediatric Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.

BMJ Case Reports
|September 13, 2019
PubMed

Insights

Simultaneous acute appendicitis in identical twin boys suggests a role for both genetic and environmental factors in disease development. This rare case highlights the need for further research into appendicitis etiology.

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Genetics

Background:

  • Acute appendicitis is a common pediatric abdominal pain cause, yet its etiology remains unclear.
  • Familial aggregation of appendicitis suggests genetic predisposition, but environmental factors are also implicated.

Observation:

  • A rare case of simultaneous acute appendicitis occurred in genetically identical monozygotic twin boys.
  • The twins shared an identical lifestyle, making the simultaneous onset unlikely due to chance alone.

Findings:

  • The simultaneous presentation strongly suggests a combined influence of genetic and environmental factors in acute appendicitis.
  • This case provides compelling evidence for multifactorial etiology in appendicitis.

Implications:

  • Understanding appendicitis in monozygotic twins can aid prompt diagnosis.
  • Further research on appendicitis incidence in twins may clarify predisposing genetic and environmental factors.

Keywords:
gastrointestinal surgerypaediatric surgery

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