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Related Experiment Video

Updated: Jan 19, 2026

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Multiple cutaneous pleomorphic leiomyosarcoma in a dog.

Naoyuki Aihara1, Junichi Sugiyama1, Hiroshi Baba2

  • 1Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.

The Journal of Veterinary Medical Science
|September 13, 2019
PubMed
Summary
This summary is machine-generated.

A dog developed multiple skin tumors diagnosed as pleomorphic leiomyosarcoma. Histopathology and immunohistochemistry confirmed these rare dermal neoplasms.

Keywords:
cutaneousdogpleomorphic leiomyosarcoma

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Area of Science:

  • Veterinary Pathology
  • Dermatology
  • Oncology

Background:

  • Canine cutaneous tumors represent a significant portion of dermatological conditions in veterinary medicine.
  • Leiomyosarcomas, tumors arising from smooth muscle, are uncommon in canine skin.

Observation:

  • A middle-aged male dog presented with multiple (15) cutaneous masses across various body sites.
  • Gross examination revealed white cut surfaces with focal red areas.
  • Microscopic evaluation showed dermal tumors composed of spindle and pleomorphic cells with eosinophilic cytoplasm and giant cells.

Findings:

  • Immunohistochemistry indicated neoplastic cells were positive for vimentin, partially for smooth muscle actin and desmin, and negative for cytokeratin.
  • The histological and immunohistochemical profile supported a diagnosis of multiple cutaneous pleomorphic leiomyosarcoma.

Implications:

  • This case highlights the potential for multiple cutaneous leiomyosarcomas in dogs.
  • Accurate diagnosis through histopathology and immunohistochemistry is crucial for understanding and managing these rare neoplasms.
  • Further research may elucidate the etiology and behavior of multiple cutaneous pleomorphic leiomyosarcomas.