Prognostic Value of Human Peripheral Monocyte Subsets for Future Coronary Events in Patients Without Significant
Manabu Kashiwagi1, Toshio Imanishi2, Yuichi Ozaki1
1Department of Cardiovascular Medicine, Wakayama Medical University.
Insights
Increased pro-inflammatory monocytes (CD14+CD16+) in human peripheral blood predict future coronary events. This finding highlights their role in coronary artery disease development and progression.
Area of Science:
- Immunology
- Cardiology
- Hematology
Background:
- Human peripheral blood monocytes are heterogeneous, classified as inflammatory (CD14+CD16-) and pro-inflammatory (CD14+CD16+) based on CD14 and CD16 expression.
- Pro-inflammatory monocytes are implicated in the pathogenesis of coronary artery disease.
Purpose of the Study:
- To investigate the association between specific human peripheral monocyte subsets and the occurrence of future coronary events.
- To determine if monocyte subset frequencies predict future cardiovascular events in patients with suspected coronary artery disease.
Main Methods:
- Enrolled 271 patients undergoing coronary angiography for suspected stable angina or silent myocardial ischemia.
- Quantified CD14+CD16- and CD14+CD16+ monocyte subsets using flow cytometry.
- Followed a medical therapy group (n=136) for future coronary events after initial coronary angiography.
Main Results:
- The frequency of CD14+CD16+ monocytes was significantly higher in patients who experienced future coronary events compared to those who did not (P<0.01).
- No significant difference in CD14+CD16+ monocyte frequencies was observed between patients with future events and those who underwent revascularization.
- Multivariate analysis identified CD14+CD16+ monocyte frequency as an independent predictor of future coronary events (P<0.01).
Conclusions:
- Elevated levels of human peripheral pro-inflammatory monocytes (CD14+CD16+) are associated with an increased risk of future coronary events.
- This subset of monocytes may serve as a valuable biomarker for predicting cardiovascular events.
Background:
Monocytes in human peripheral blood are heterogeneous and can be divided into 2 groups, inflammatory and pro-inflammatory, according to the differential expression of CD14 and CD16. Pro-inflammatory monocytes (CD14+CD16+) seem to contribute to the development of coronary artery disease. This study aimed to investigate the involvement of specific human peripheral monocyte subsets in the development of future coronary events.
Methods And Results:
We enrolled 271 patients who were suspected to have either stable angina pectoris or silent myocardial ischemia and underwent coronary angiography (CAG). Two monocyte subsets (CD14+CD16-and CD14+CD16+) were measured by flow cytometry. Patients who did not undergo coronary artery revascularization at initial CAG were followed as the medical therapy group, which included 136 patients among whom 15 had future coronary events. The frequency of CD14+CD16+monocytes was significantly higher in patients who had future coronary events than in those who did not (P<0.01). Furthermore, the frequencies of CD14+CD16+monocyte were not significantly different between patients who had future coronary events and those who underwent coronary revascularization at initial CAG (P<0.33). Multivariate analysis revealed that the frequency of CD14+CD16+monocytes was an independent predictor for future coronary events (P<0.01).
Conclusions:
An increase in the abundance of human peripheral pro-inflammatory monocytes is related to the development of future coronary events.
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