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REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells

Lei Zhou1, Liangfang Yao1, Qing Zhang2

  • 1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, P. R. China.

Cellular & Molecular Immunology
|September 13, 2019
PubMed
Summary

REGγ deficiency in dendritic cells exacerbates autoimmune neuroinflammation by enhancing Interleukin-17A-producing helper T cell differentiation. This occurs through increased integrin αvβ8 expression, driven by impaired proteasomal degradation of IRF8.

Keywords:
DCEAEREGγTGF-βTh17

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