A Syrian Child with Intussusception Caused by a Diffuse Large B-Cell Lymphoma

Area of Science:

• Gastroenterology
• Pediatric Surgery
• Oncology

Background:

• Intussusception, the telescoping of one bowel segment into another, is common in infants but rare in older children.
• In older children, intussusception often presents with nonspecific symptoms, complicating diagnosis.
• Malignancy as a lead point for intussusception is uncommon but must be considered in this age group.

Observation:

• An 11-year-old boy presented with acute abdominal pain and weight loss, symptoms suggestive of intussusception.
• Imaging revealed ileocolic intussusception with an obstructing mass.
• The mass was surgically resected along with affected bowel and lymph nodes.

Findings:

• Histological examination confirmed diffuse large B-cell Non-Hodgkin's lymphoma as the cause of intussusception.
• This specific lymphoma subtype is uncommon in the Middle East.
• The patient's presentation mimicked more common pediatric intussusception cases.

Implications:

• This case highlights the importance of investigating lead points in older children with intussusception.
• It underscores the need to consider malignancy, even rare types, in the differential diagnosis.
• Prompt surgical intervention and histological analysis are vital for accurate diagnosis and management of pediatric intussusception.