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Sex-Based Differences in Inpatient Burn Mortality.

Felicia N Williams1,2, Paula D Strassle3,4, Laquanda Knowlin5

  • 1Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA. fnwmd@med.unc.edu.

World Journal of Surgery
|September 13, 2019
PubMed
Summary

Female burn patients face a higher mortality risk, even when accounting for other factors. This study highlights significant sex-based differences in burn outcomes that require further attention in research and treatment.

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Area of Science:

  • Trauma surgery
  • Burn care research
  • Clinical outcomes research

Background:

  • Conflicting research exists regarding sex-based differences in burn patient mortality.
  • While females may have increased mortality risk in burn injuries, the opposite is observed in non-burn trauma.
  • This study aimed to clarify sex-based disparities in burn mortality and identify contributing factors.

Purpose of the Study:

  • To determine if sex-based differences in burn mortality exist.
  • To assess if patient demographics, comorbidities, and injury characteristics explain these differences.
  • To provide evidence for sex-specific considerations in burn care.

Main Methods:

  • Analysis of adult burn patients admitted between 2004 and 2013.
  • Utilized inverse probability of treatment weights (IPTW) and inverse probability of censor weights (IPCW) for confounding adjustment.
  • Employed weighted Kaplan-Meier survival curves to estimate 30-day and 60-day mortality risk by sex.

Main Results:

  • Females were older and more likely to have diabetes, pulmonary disease, heart failure, scald burns, and inhalational injuries.
  • Despite statistical adjustments, females remained over twice as likely to experience 60-day mortality (RR 2.87).
  • Significant sex-based differences in mortality risk were observed.

Conclusions:

  • Female burn patients exhibit a significantly higher risk of 60-day mortality.
  • This increased risk persists even after controlling for demographics, comorbidities, and injury characteristics.
  • Future research and clinical interventions should address these identified sex-based differences in burn patient outcomes.