[Determination of phenotypic characteristics of chronic obstructive lung disease in elderly patients.]

This study looks at the assessment parameters and their informing value for the phenotypic stratification of elderly patients with chronic obstructive pulmonary disease (COPD). Using cluster analysis all patients were divided into subgroups (phenotypes). For women, phenotypic cluster K1: patients with a normal body weight, with disease duration more than 5 years; with a frequency of exacerbations less than 2 times a year. Phenotypic cluster K2: elderly patients, but younger than in K1, overweight, with a disease duration less than 5 years, with a frequency of exacerbations less than 2 times a year, but lesser than in K1, with a history of asthma in 66% of cases. 3 phenotypes were identified for men: K1 - overweight, disease duration of about 6 years, with a frequency of exacerbations more than 2 times a year; K2 - patients with body weight deficiency, disease duration more than 7 years, frequency of exacerbations less than 2 times a year; K3 - overweight, disease duration more than 8 years, with a frequency of exacerbations less than 2 times a year. COPD main signs of phenotyping in elderly patients were determined: gender, disease duration, body mass index, frequency of exacerbations. This allowed to identify 2 phenotypes in women: COPD with in frequent exacerbations and phenotype with presence of syndrome BA-COPD; in men - 3 phenotypes: bronchitis's, emphysematous and COPD with a slowly progressive course.