[Non-cemented modular prosthetic reconstruction for bone defect after tumor resection in lower extremities]

Area of Science:

• Orthopedic oncology
• Biomaterials science
• Surgical reconstruction

Background:

• Lower extremity tumor resections often require complex reconstructions.
• Non-cemented modular prostheses are increasingly used for limb salvage surgery.
• Evaluating the clinical outcomes and failure modes of these prostheses is crucial.

Purpose of the Study:

• To assess the preliminary clinical results of the MEGASYSTEM-C non-cemented modular prosthesis.
• To identify prognostic factors associated with prosthetic failure after lower extremity tumor resection.

Main Methods:

• Retrospective analysis of 150 patients treated with MEGASYSTEM-C prostheses.
• Data collected on patient demographics, tumor type, reconstruction site, and oncologic outcomes.
• Prosthetic survival, failure modes (classified by Henderson et al.), and functional outcomes (MSTS score) were analyzed.
• Kaplan-Meier survival analysis and Log-Rank tests were employed.

Main Results:

• The 3-year and 5-year prosthesis survival rates were 94.4% and 92.5%, respectively.
• Prosthetic failure occurred in 16.0% of patients, with various failure types reported.
• Tumor progression and infection were identified as significant factors affecting early prosthetic survival.
• Musculoskeletal Tumor Society (MSTS) scores indicated good functional outcomes across different reconstruction sites.

Conclusions:

• The MEGASYSTEM-C non-cemented modular prosthesis demonstrates favorable short-term outcomes for lower extremity bone defects post-tumor resection.
• Good functional results and a low complication rate were observed.
• Proactive management of tumor progression and infection is essential for optimizing prosthetic longevity.