Quantitative bioanalytical LC-MS/MS assay for S130 in rat plasma-application to a pharmacokinetic study

Yanping Guan1,2,3, Yuanyuan Fu2,4, Yao Liu1,2

  • 1Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.

Bioanalysis
|September 13, 2019
PubMed

Related Concept Videos

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs10:02

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Rabbits are widely used to study the pharmacokinetics of intraocular drugs. We describe a method for conducting pharmacokinetic studies of intraocular drugs using rabbit...
33.3K
Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells07:37

Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

A high-throughput cold physical plasma treatment protocol of liquids and cells is shown. It involves setting up different feed gas compositions for plasma ignition, measuring the plasma's emission spectra, and the subsequent analysis of liquids and cellular activity after plasma...
13.3K
Development and Testing of Species-specific Quantitative PCR Assays for Environmental DNA Applications08:54

Development and Testing of Species-specific Quantitative PCR Assays for Environmental DNA Applications

Environmental DNA assays require rigorous design, testing, optimization and validation before the collection of field data can begin. Here, we present a protocol to take users through each step of designing a species-specific, probe-based qPCR assay for the detection and quantification of a target species DNA from environmental...
15.8K
Rat Mesentery Angiogenesis Assay18:30

Rat Mesentery Angiogenesis Assay

Normal adult vascularized mammalian tissue that lacks physiologic angiogenesis and that has not been exposed to surgical intervention is used to study: (i) the initiation and development of angiogenesis following intraperitoneal administration of test agents; and (ii) modification of angiogenesis following systemic administration of selected test...
14.2K
A Platelet-Rich Plasma Injection into the Sectioned Achilles Tendon of a Rat04:31

A Platelet-Rich Plasma Injection into the Sectioned Achilles Tendon of a Rat

This video demonstrates a technique for injecting platelet-rich plasma (PRP) into the sectioned Achilles tendon of rats. A small segment is excised from the Achilles tendon of a recipient rat, the site is sutured, and the rat is allowed to recover. Concurrently, whole blood is collected from a donor rat and centrifuged to obtain PRP, which is then activated and injected into the sutured site of the recipient rat to induce tendon...
459
A Quantitative Assessment of the Phagocytosis of Allogeneic and Xenogeneic Erythrocytes by Rat Macrophages In Vitro09:01

A Quantitative Assessment of the Phagocytosis of Allogeneic and Xenogeneic Erythrocytes by Rat Macrophages In Vitro

This work describes a standardized in vitro protocol to quantify and compare the phagocytosis rates of xenogeneic (human) and allogeneic (rat) red blood cells by isolated rat...
451