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Multidrug resistance as a cause of steroid-nonresponsive downgrading type I reaction in Hansen's disease
Surabhi Sinha1, Kabir Sardana1, Diksha Agrawal1
1Department of Dermatology, STD and Leprosy, Dr. RML Hospital and PGIMER, New Delhi, India.
International Journal of Mycobacteriology
|September 13, 2019
Abstract:
While Type 1 reaction in Hansen's disease is commonly encountered, the triggers and reasons for its persistence are not well understood even though the immunological milieu and cytokine interplay have been studied. Herein, we present a case of Type 1 downgrading reaction in which multidrug resistance was the probable cause of steroid-nonresponsiveness and which responded promptly on starting alternate antileprosy treatment.