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Related Experiment Video

Updated: Jan 19, 2026

Kupffer Cell Isolation for Nanoparticle Toxicity Testing
09:49

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Published on: August 18, 2015

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Nanoparticles Toxicity in Fish Models.

Jimena Cazenave1,2, Analía Ale1, Carla Bacchetta1

  • 1Instituto Nacional de Limnologia, CONICET, UNL, Santa Fe, Argentina, Paraje El Pozo, Ciudad Universitaria UNL, 3000 Santa Fe, Argentina.

Current Pharmaceutical Design
|September 13, 2019
PubMed
Summary

Nanoparticle (NP) toxicity research in fish models is limited, with silver and titanium NPs being most studied. More research is needed, especially on marine fish, to understand nanotoxicity risks.

Keywords:
Nanoecotoxicologyanimal modelbibliometric analysisengineered nanomaterialsoxidative stressphysicochemical propertiestoxic mechanisms.

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Area of Science:

  • Environmental Science
  • Toxicology
  • Ecotoxicology

Background:

  • Nanoparticle (NP) production and usage are increasing globally.
  • Concerns exist regarding potential human and environmental health toxicity.
  • Fish are valuable models for assessing nanotoxicity.

Purpose of the Study:

  • To review and assess current knowledge on nanotoxicity in fish models.
  • To identify key factors, mechanisms, and knowledge gaps in NP toxicity research.
  • To quantitatively evaluate the scientific literature on nanotoxicity and fish.

Main Methods:

  • Systematic literature search of Scopus database (up to February 2019).
  • Bibliometric analysis of research on nanoparticles, nanotoxicity, and fish.
  • Narrative synthesis of factors and mechanisms of NP toxicity in fish.

Main Results:

  • Scientific production on nanotoxicity in fish is low compared to general NP research.
  • Silver and titanium NPs are the most studied nanomaterials.
  • Danio rerio is the most frequently used fish model; marine fish research is scarce.
  • Several factors, effects, and toxicity mechanisms of NPs in fish were identified.

Conclusions:

  • There is a significant knowledge gap in fish nanotoxicity research.
  • Further research is crucial to understand and mitigate NP risks to aquatic ecosystems.
  • Future studies should focus on underrepresented areas, such as marine fish and diverse nanomaterials.