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Updated: Jan 19, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
11:07

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding

Published on: September 21, 2011

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Nuclear action of FGF members in endocrine-related tissues and cancer: Interplay with steroid receptor pathways

Virginia Figueroa1, María Sol Rodríguez1, Claudia Lanari1

  • 1Instituto de Biología y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, Argentina.

Steroids
|September 13, 2019
PubMed

Insights

Fibroblast growth factor (FGF) signaling impacts nuclear functions, influencing steroid receptors and gene transcription. Understanding FGF/FGFR nuclear actions is key to targeting endocrine-related diseases and breast cancer.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Cancer Research

Background:

  • Dysregulation of fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling is linked to various human disorders.
  • Several FGF members are found in the nuclear compartment, suggesting roles beyond cell surface signaling.
  • Steroid receptors form nuclear complexes to activate gene transcription upon hormone binding or ligand-independent activation.

Purpose of the Study:

  • To review the interplay between steroid receptor and FGF/FGFR pathways.
  • To summarize current knowledge on the nuclear actions of FGF members in endocrine tissues and cancer.
  • To highlight the role of nuclear FGF/FGFR signaling in endocrine-resistant breast cancer.

Main Methods:

  • Literature review focusing on nuclear trafficking and targets of FGF/FGFR members.
  • Analysis of evidence detailing the interplay between FGF/FGFR and steroid hormones/receptors.
  • Summary of data on aberrant FGF/FGFR signaling and its nuclear effects.

Main Results:

  • FGF/FGFR members exhibit nuclear localization and interact with steroid hormone pathways.
  • Nuclear FGF/FGFR signaling influences gene transcription, particularly in endocrine-related tissues.
  • Aberrant FGF/FGFR signaling contributes to endocrine resistance in breast cancer.

Conclusions:

  • Understanding the nuclear functions of FGF/FGFR is crucial for developing targeted therapies.
  • Investigating FGF-induced endocrine resistance mechanisms can improve treatment strategies for hormone receptor-positive tumors.
  • Targeting nuclear FGF/FGFR actions may enhance or restore endocrine sensitivity in endocrine-related diseases.
Keywords:
Breast cancerEndocrine resistanceEndocrine-related tissues and cancerFGF/FGFR axisNuclear FGF/FGFRSteroid receptor pathway

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