The current work describes a protocol for running the Pathway2Targets algorithm, an R script that predicts and prioritizes therapeutic targets based on the profile of intracellular signaling pathways generated by comparing case versus control samples from a bulk RNA-sequencing...

This protocol presents the acetylcholine rechallenge after nitroglycerine as an add-on procedure to spasm provocation testing. The purpose of this technique is to unmask co-existing microvascular spasm in patients with epicardial spasm and to assess the protective efficacy of nitroglycerine on a per-patient level to guide medical...

Global marketing is a complex field where businesses encounter a range of challenges as they expand into international markets. These challenges can stem from internal factors, such as strategic misalignment, communication breakdowns, and operational inefficiencies. Understanding and addressing these barriers is essential for companies aiming to establish a successful presence abroad.
One of the primary obstacles is the development of non-country-specific marketing strategies. When businesses...

This method describes the generation of organotypic cerebellar cultures and the effect of certain apoptotic stimuli on the viability of different cerebellar cell types.

Market challengers use different strategies to disrupt industry leaders and gain market share by leveraging their strengths and market insights. One such strategy is the Full-Frontal Attack, where the challenger directly competes with the market leader by mirroring its product offerings, pricing, and promotional strategies. This approach requires significant financial and operational resources to match the leader in every aspect of the business. For example, Samsung has employed a Full-Frontal...

Here, we present a protocol that manipulates interlocutor visibility to examine its impact on gesture production in interpersonal communication. This protocol is flexible to tasks implemented, gestures examined, and communication modality. It is ideal for populations with communication challenges, such as second language learners and individuals with autism spectrum...