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Updated: Jan 19, 2026

Transarterial Administration of Oncolytic Viruses for Locoregional Therapy of Orthotopic HCC in Rats
Published on: April 15, 2016
Development of a Nursing Policy for the Administration of an Oncolytic Virus in the Outpatient Setting
Vania Hom1, Emoke Karonis1, Tara Sigidi1
1Memorial Sloan Kettering Cancer Institute, New York, NY.
Objective:
To describe the development of a nursing policy for the administration of oncolytic viruses in therapeutic clinical trials and the unique challenges for infection control and nursing.
Data Source:
Journal articles, web-based resources, peer-reviewed literature.
Conclusion:
Early nursing involvement and inclusion of multidisciplinary hospital departments facilitated the creation of a nursing policy that maintained fidelity to the research protocol and minimized potential risk to nursing staff. A total of 18 doses of oncolytic viruses were administered with no inadvertent exposures to staff or other patients of the oncolytic virus.
Implications For Nursing Practice:
Nursing should be involved at the initiation of a clinical trial to determine whether policies need to be created or changed to maintain the integrity of the research protocol while ensuring the safety of staff and patients.
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