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A case report on anti-Mia antibody in a multi-transfused patient from India

Soma Agrawal1, Mohit Chowdhry1

  • 1Department of Transfusion Medicine, Indraprastha Apollo Hospitals, New Delhi, 110076, India.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|September 14, 2019
PubMed

Insights

Anti-Mia antibody, part of the MNSs blood group system, can cause transfusion reactions and hemolytic disease in newborns. This case report highlights its presence in a multi-transfused Indian patient, addressing a gap in regional literature.

Area of Science:

  • Immunohaematology
  • Blood group serology

Background:

  • The MNSs blood group system includes the GP.Mur antigen, associated with the anti-Mia antibody.
  • Anti-Mia antibodies are clinically significant, potentially causing severe transfusion reactions and hemolytic disease of the newborn (HDFN).
  • Limited published data exists on anti-Mia antibodies within the Indian population.

Observation:

  • This study reports a case of anti-Mia antibody identified in a patient receiving multiple blood transfusions.
  • The patient's clinical history and serological findings are detailed.

Findings:

  • Confirmation of anti-Mia antibody in a multi-transfused patient from India.
  • The presence of this antibody underscores the importance of thorough blood group genotyping and antibody screening in transfusion medicine.

Implications:

  • This case contributes valuable data on anti-Mia antibody prevalence in India.
  • Highlights the need for awareness and appropriate management strategies for anti-Mia antibodies in transfusion services.
  • Emphasizes the clinical significance of rare blood group antibodies in diverse patient populations.
Keywords:
Anti-MiaMia antigenMiltenberger series

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