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Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

The fate of the replisome following a collision with a head-on RNA polymerase (RNAP) is unknown. We find that the replisome stalls upon collision with a head-on RNAP, but resumes elongation after displacing the RNAP from DNA. Mfd promotes replication restart by facilitating displacement of the RNAP after the...
14.0K
Effects of Thinking Abstractly or Concretely on Self-control08:31

Effects of Thinking Abstractly or Concretely on Self-control

Source: Diego Reinero & Jay Van Bavel—New York University
Whether it's refraining from having a second serving of ice cream, studying instead of attending a fun party, or deciding to put money away in a savings account, sacrificing short-term outcomes in favor of long-term outcomes (i.e., delaying gratification) is a central tenant of self-control. When people apply self control, they engage numerous psychological processes to help them achieve their goal. These self-regulatory...
6.8K
Quaternary Structure Modeling Through Chemical Cross-Linking Mass Spectrometry: Extending TX-MS Jupyter Reports05:18

Quaternary Structure Modeling Through Chemical Cross-Linking Mass Spectrometry: Extending TX-MS Jupyter Reports

Targeted cross-linking mass spectrometry creates quaternary protein structure models using mass spectrometry data acquired using up to three different acquisition protocols. When executed as a simplified workflow on the Cheetah-MS web server, the results are reported in a Jupyter Notebook. Here, we demonstrate the technical aspects of how the Jupyter Notebook can be extended for a more in-depth...
2.6K
Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry16:11

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

This article describes an experimental protocol using electrospray-ion mobility-mass spectrometry, semi-empirical quantum calculations, and energy-resolved threshold collision-induced dissociation to measure the relative thermochemistry of the dissociation of related ternary metal...
2.7K
Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

The application of high-frequency low-energetic stimulation can alleviate the symptoms of gastric dysmotility. In this research, a miniature, endoscopically implantable and wirelessly rechargeable device which is implanted into a submucosal pocket is presented. Successful both-way communication and stimulation control were achieved during an experiment on live...
8.9K
Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE06:57

Modeling Verbal Behavior Deficits with the Stimulus Control Ratio Equation, SCoRE

This article describes the procedures for conducting a verbal operant analysis (VOA), calculating the stimulus control ratio equation (SCoRE), and developing individualized verbal behavior treatment plans, specifically significant to address the deficits characteristic of...
10.9K