High mean platelet volume to platelet count ratio as a predictor on poor outcomes after CABG

Area of Science:

• Cardiovascular Surgery
• Hematology
• Surgical Outcomes Research

Background:

• Platelet indices, including mean platelet volume (MPV) and platelet count (PC), are increasingly recognized as potential biomarkers in cardiovascular disease.
• The ratio of MPV to PC has not been extensively studied in the context of outcomes following coronary artery bypass grafting (CABG).

Purpose of the Study:

• To investigate the association between the MPV/PC ratio and postoperative outcomes in patients undergoing CABG.
• To evaluate the impact of the MPV/PC ratio on early mortality and long-term survival rates after CABG.

Main Methods:

• A retrospective review of 213 consecutive patients who underwent CABG between February 2016 and September 2018.
• Patients were stratified into high and low MPV/PC ratio groups based on a cut-off value of 3.825.
• Statistical analysis was performed to identify predictors of various postoperative outcomes and mortality.

Main Results:

• Patients with a high MPV/PC ratio (n=72) exhibited significantly higher rates of reoperation for early vein-graft occlusion, low cardiac output syndrome, and respiratory complications compared to the low MPV/PC ratio group (n=141).
• A higher MPV/PC ratio was associated with a longer mean hospital length of stay.
• The MPV/PC ratio was identified as an independent predictor for reoperation due to early vein-graft occlusion, sepsis, and late mortality.

Conclusions:

• An elevated MPV/PC ratio is a significant predictor of adverse early postoperative outcomes, including early vein-graft occlusion, following CABG.
• The MPV/PC ratio also demonstrates a detrimental effect on long-term survival rates in patients who have undergone CABG.