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Updated: Jan 19, 2026

Using a Comparative Species Approach to Investigate the Neurobiology of Paternal Responses
Published on: September 19, 2011
[Influence of uniparental disomy on the conclusion of paternity testing]
1Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.ychslshx@126.com.
Objective:
To explore the influence of uniparental disomy (UPD) on bipartite and tripartite paternity testing.
Methods:
Two cases of paternity testing were analyzed by multiplex amplification and capillary electrophoresis typing. Suspected UPD was verified by using single nucleotide polymorphism array (SNP array). Parental power index was calculated by using a bipartite or tripartite model.
Results:
The two cases were found to harbor respectively three short tandem repeats on chromosome 2 and two short tandem repeats on chromosome 15. SNP array verified that both cases were of UPD. Case 1 had a parental power index of 122274987565.23 by a tripartite model, while case 2 had a parental power index of 13500.8463 by a bipartite model. Based on the technical specification, the conclusions supported a biological parent-child relationship in both cases.
Conclusion:
UPD may lead to misjudgment of paternity testing. The possibility of UPD should be considered when certain loci which do not conform to Mendelian inheritance have aggregated to one chromosome.
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